Drug Name】Vitamin E and Three Oils Soft Capsules

Ingredients】This product is a compound preparation, the composition of which is as follows: each capsule contains vitamin E50mg, essential fish oil 200mg, evening primrose oil 125mg, thuja oil 125mg.

[Properties] This product is a gelatin pill containing yellow or dark yellow oily liquid.

【Indications】Applied to hyperlipidemia.

【Use and Dosage】Orally. 1~2 capsules at a time, twice a day.

Adverse effects]: Nausea, constipation and other reactions, can be alleviated after continuing to use the drug.

Contraindication] It is forbidden for those who are allergic to the ingredients of this product.

Precautions

1. Interference with diagnosis: large amounts of vitamin E can lead to increased serum cholesterol and serum triglyceride concentrations.

2. For patients with hypoprothrombinemia and iron deficiency anemia caused by vitamin K deficiency, the drug should be used with caution to avoid aggravation of the condition. (For pregnant women and lactating women] Pregnant women intake of normal diet, has not been found to have a definite deficiency of vitamin E. Vitamin E can partially pass through the placenta, and the fetus only obtains 20% to 30% of the mother's blood concentration, so low birth weight infants, after birth, can be due to low storage of this product deficiency.

Children's medication] is not clear.

[For the elderly] is not clear.

Drug interactions

1. A large amount of aluminum hydroxide can precipitate bile acids in the upper part of the small intestine, reducing the absorption of fat-soluble vitamin E.

2. Avoid the use of coumarin and its derivatives with large amounts of vitamin E to prevent hypoprothrombinemia.

3. Lipid-lowering drugs, such as kaulethylene amine and kaulethipol, mineral oil and aluminum sulfate, can interfere with vitamin E absorption.

4. Iron deficiency anemia increases the need for vitamin E when iron supplementation.

5. Vitamin E can promote the absorption of vitamin A, intrahepatic vitamin A storage and utilization increase, and reduce the occurrence of vitamin A toxicity; but excess can reduce the vitamin A body storage.

Overdose] Vitamin E can cause blurred vision, enlarged mammary glands, dizziness, headache, flu-like syndrome, diarrhea, stomach cramps and weakness and weakness, and occasionally can cause uric acidosis. Vitamin K deficiency patients can cause bleeding symptoms.

Pharmacology and Toxicology

1.Pharmacology Vitamin E belongs to antioxidants, can be combined with dietary selenium, to prevent the membrane and other cellular structures of the polyvalent unsaturated ester acid from free radicals damage; protection of erythrocytes from hemolysis, protection of nerves and muscles from oxygen radicals damage, to maintain the normal development of nerves, muscles and function of the two if it may also be some of the enzyme system of cofactors. Essential fish oil is mainly composed of ethyl eicosapentaenoic acid and ethyl docosahexaenoic acid, containing more unsaturated bonds, has a strong role in adjusting blood lipids, and also has vasodilatation and anti-thrombotic effect. The mechanism of action is to promote neutral or acidic cholesterol from fecal excretion, inhibit intrahepatic lipid and lipoprotein synthesis, can reduce plasma cholesterol, triglyceride, LDL, VLDL, and increase HDL.Evening Primrose Oil has the effect of lowering triglyceride, cholesterol and B-lipoprotein.

2.Toxicology: Toxicology test proved that the acute toxicity test in mice got the maximum drug resistance of 14.74g/Kg, so this product has no obvious toxic side effects.

Pharmacokinetics] Vitamin E 50% ~ 80% in the intestinal absorption (duodenum), absorption requires the presence of bile salts and dietary fat as well as normal pancreatic function, and the blood B-lipoproteins, stored in the systemic tissues, especially in the adipose tissue, the amount of storage can be as high as 4 years for the needs of hepatic metabolism, through the bile and renal excretion.

Storage] Keep in a dry place, sealed and protected from light.

Package】Pharmaceutical plastic bottle, 120 capsules/bottle.

Effective period]: 24 months.

Execution Standard]: Local standard of chemical drugs rising national standard book IV WS-10001-(HD-0378)-2002

[Approval Number] National Drug License H20053041